Ouabain-Insensitive Sodium Movements in the Human Red Blood Cell
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منابع مشابه
Ouabain-Insensitive Sodium Movements in the Human Red Blood Cell
Red blood cells exposed to ouabain are capable of net Na outflux against an electrochemical gradient; the net outflux is inhibited by the diuretic, furosemide. In ouabain-treated cells, both the unidirectional Na outflux and the unidirectional Na influx are inhibited by furosemide. Furosemide also inhibits the ouabain-sensitive Na-Na exchange accomplished by the Na-K pump in K-free solutions. F...
متن کاملSodium Movements in the Human Red Blood Cell
Measurements were made of the sodium outflux rate constant, (o)k(Na), and sodium influx rate constant, (i)k(Na), at varying concentrations of extracellular (Na(o)) and intracellular (Na(c)) sodium. (o)k(Na) increases with increasing [Na(o)] in the presence of extracellular potassium (K(o)) and in solutions containing ouabain. In K-free solutions which do not contain ouabain, (o)k(Na) falls as [...
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متن کاملOuabain-insensitive salt and water movements in duck red cells. II. The role of chloride in the volume response
This paper describes the effect of external chloride on the typical swelling response induced in duck red cells by hypertonicity or norepinephrine. Lowering chloride inhibits swelling and produces concomitant changes in net movements of sodium and potassium in ouabain-treated cells, which resemble the effect of lowering external sodium or potassium. Inhibition is the same whether chloride is re...
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ژورنال
عنوان ژورنال: Journal of General Physiology
سال: 1971
ISSN: 1540-7748,0022-1295
DOI: 10.1085/jgp.57.3.259